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Which disorder is associated with abnormal pigmentation caused by skin damage?

  1. Lentigines

  2. Vitiligo

  3. Albinism

  4. Melasma

The correct answer is: Lentigines

Lentigines are indeed associated with abnormal pigmentation caused by skin damage. They are often referred to as "sunspots" or "age spots" and develop as a result of prolonged exposure to ultraviolet (UV) light, which leads to an increase in melanin production. These pigmented lesions typically appear on sun-exposed areas of the skin, such as the face, hands, and arms, and increase in number with age. The formation of lentigines signifies the skin's response to damage, indicating a protective mechanism where the body produces more pigments to shield the deeper layers of skin from UV radiation. In contrast, vitiligo is characterized by the loss of pigmentation due to the destruction of melanocytes, leading to patches of lighter skin rather than abnormal pigmentation. Albinism is a genetic condition resulting in a lack of melanin production, resulting in lighter skin, hair, and eyes, but is not related to skin damage. Melasma, while it involves hyperpigmentation, is typically triggered by hormonal changes rather than direct skin damage. Hence, the association of lentigines with skin damage and abnormal pigmentation emphasizes their role as indicators of sun-induced changes in the skin.